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Profil
| Derzeitige Stellung | Professor W-3 und Äquivalente |
|---|---|
| Fachgebiet | Medizinische Mikrobiologie und Mykologie, Hygiene, Molekulare Infektionsbiologie,Biochemie |
| Keywords | Oral vaccines, RNAj, Protein transport, Cell differentiation, Giardia |
Aktuelle Kontaktadresse
| Land | Argentinien |
|---|---|
| Ort | Cordoba |
| Universität/Institution | Universidad Catolica de Cordoba |
| Institut/Abteilung | Centro de Investigacion y Desarrollo en Inmunologia y Enfermedades Infecciosas (CIDIE-CONICET) |
Gastgeber*innen während der Förderung
| Prof. Dr. Tim Sparwasser | Institut für Molekulare Bakteriologie, TWINCORE Zentrum für Experimentelle und Klinische Infektionsforschung GmbH, Hannover |
|---|---|
| Prof. Dr. Tim Sparwasser | Institut für Medizinische Mikrobiologie und Hygiene, Johannes Gutenberg-Universität Mainz, Mainz |
| Beginn der ersten Förderung | 01.03.2017 |
Programm(e)
| 2016 | Georg Forster-Forschungspreis-Programm |
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Projektbeschreibung der*des Nominierenden
| Professor Lujan is an international authority in the study of the molecular basis of cellular differentiation and adaptation of early-branching eukaryotic organisms, in particular of those acting as human pathogens. Professor Lujan has discovered the molecular mechanism controlling antigenic variation in the intestinal parasite Giardia lamblia, was able to disrupt this process that allows the microorganism to avoid the immune response of its hosts and developed the first oral vaccine composed solely of surface antigens of Giardia. Since these proteins protect the parasite in the harsh environment of the upper intestinal tract and since they are highly immunogenic, Professor Lujan designed an oral vaccine platform composed by Virus-like Particles covered with those Giardia molecules to deliver vaccinal antigens by the oral route. In Germany, he continues his research on the development of oral vaccines against Mycobacterium tuberculosis and other respiratory pathogens. |
Publikationen (Auswahl)
| 2019 | Marianela C. Serradell, Lucía L. Rupil, Román A. Martino, César G. Prucca, Pedro G. Carranza, Alicia Saura, Elmer A. Fernández, Pablo R. Gargantini, Albano H. Tenaglia, Juan P. Petiti, Renata R. Tonelli, Nicolás Reinoso-Vizcaino, José Echenique, Luciana Berod, Eliane Piaggio, Bertrand Bellier, Tim Sparwasser, David Klatzmann, Hugo D. Luján: Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins. In: Nature Communications , 2019, 361-365 |
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| 2018 | Hugo D. Lujan, Tim Sparwasser, Marianela C. Serradella, Pablo R. Gargantinia et al. Cytokines, antibodies and histopathological profiles during Giardia infection and VSP-based vaccination. In: Infection and Immunity, 2018, |
| 2018 | Hugo Dr. Lujan, Tim D. Sparwasser, Lis Noelia Velasquez, Philipp Stüve, Maria Virginia Gentilini et al.: Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses. In: Front Immunol - Frontiers in Immunology, 2018, 471 |